Process Simulation of Twin‐Screw Granulator: Effect of Screw Configuration on Size Distribution

The effect of screw configuration on granule size distribution (GSD) using gPROMS FormulatedProduct (gFP) software to perform optimization, estimation complex processes, and analyses is evaluated. Twin-screw granulation modeling was used investigate the contribution liquid-to-solid (L/S) ratio GSD. Lactose Avicel were granulating materials. Twelve different configurations investigated under three feed rates as consistent with literature at various L/S ratios. Results indicate that kneading elements promote recovery 100–1000 µm granules while reducing production oversized granules. Higher support fines agglomerates, a low rate produces